STEPTRACKERHIGH-YIELD RAPID REVIEW | PATHOLOGY · BIOCHEMISTRY · MICROBIOLOGY · IMMUNOLOGY · PHARMACOLOGY

USMLE Step 1 Rapid Review

PART IBacteriologyChapters 01–04 · 24 pages
01

Bacterial Basics

1.01Bacterial structure & cell wallGram-positive vs gram-negative walls · capsule · LPS · spores · pili, flagellaOpen →1.02Stains, culture & lab identificationGram, acid-fast, special stains · selective and differential media · growth requirementsOpen →1.03ExotoxinsToxins by mechanism: ADP-ribosylating, protein synthesis, cAMP, neurotoxins, lysinsOpen →1.04Endotoxin, superantigens & virulence factorsLipid A · septic shock · TSST-1 · protein A, IgA protease, M proteinOpen →1.05Bacterial geneticsTransformation · conjugation · transduction · transposition · lysogenic toxinsOpen →1.06Identification algorithmsGram-positive cocci and rods · gram-negative lactose and oxidase treesOpen →
02

Gram-Positive Bacteria

2.01StaphylococciS aureus diseases and toxins · S epidermidis · S saprophyticus · MRSAOpen →2.02Streptococci I — S pyogenes & S agalactiaeGroup A: pharyngitis, skin, rheumatic fever, PSGN · group B: neonatal sepsisOpen →2.03Streptococci II — pneumococcus, viridans & enterococciS pneumoniae · viridans strep · S gallolyticus · Enterococcus, VREOpen →2.04ClostridiaC tetani · C botulinum · C perfringens · C difficileOpen →2.05Bacillus, Listeria & CorynebacteriumAnthrax · B cereus · Listeria · diphtheriaOpen →2.06Actinomyces & NocardiaBranching rods: anaerobe vs aerobe, sulfur granules vs acid-fastOpen →
04

Gram-Negative Bacteria

4.01NeisseriaN meningitidis vs N gonorrhoeae · complement deficiency · neonatal conjunctivitisOpen →4.02Haemophilus, Bordetella & MoraxellaH influenzae type b · H ducreyi · pertussis stages · MoraxellaOpen →4.03Pseudomonas & LegionellaPseudomonas infections and toxins · Legionnaires disease · Pontiac feverOpen →4.04EnterobacteriaceaeE coli strains · Klebsiella · Proteus · Serratia · EnterobacterOpen →4.05Enteric pathogensSalmonella · Shigella · Campylobacter · Yersinia · VibrioOpen →4.06Helicobacter pyloriUrease · gastritis, ulcers, MALT lymphoma, adenocarcinoma · triple therapyOpen →4.07Zoonotic bacteriaBartonella · Brucella · Francisella · Pasteurella · Y pestis · Coxiella · LeptospiraOpen →4.08SpirochetesSyphilis stages · Lyme disease · relapsing fever · leptospirosisOpen →4.09Anaerobes & other gram-negativesBacteroides · Fusobacterium · Gardnerella · HACEK · Klebsiella granulomatisOpen →
PART IIVirologyChapters 05–07 · 13 pages
07

RNA Viruses

7.01Picornaviruses & calicivirusesPolio · coxsackie · echovirus · rhinovirus · hepatitis A · norovirusOpen →7.02Orthomyxo- & paramyxovirusesInfluenza shift and drift · measles · mumps · RSV · parainfluenzaOpen →7.03Arboviruses & hemorrhagic fever virusesDengue, yellow fever, Zika, West Nile · chikungunya · Ebola · hantavirusOpen →7.04Rotavirus, coronaviruses & rabiesRotavirus · SARS-CoV-2 · rabies · rubellaOpen →7.05Hepatitis virusesHAV–HEV · HBV serology · HCV · HDV coinfectionOpen →7.06HIV I — virus, diagnosis & courseStructure · life cycle · tests · natural historyOpen →7.07HIV II — opportunistic infectionsInfections and cancers by CD4 count · prophylaxisOpen →7.08Prions & slow infectionsCreutzfeldt-Jakob · variant CJD · kuru · fatal familial insomnia · SSPE, PMLOpen →
PART IIIMycology & ParasitologyChapters 08–09 · 8 pages
PART IVClinical Microbiology & AntimicrobialsChapters 10–12 · 20 pages
10

Infections by System

10.01Pneumonia by setting & ageCommunity, hospital, aspiration, atypical · organisms by age · cluesOpen →10.02Meningitis & CNS infectionsOrganisms by age · CSF patterns · encephalitis · brain abscessOpen →10.03Diarrhea & food poisoningBloody vs watery · incubation clues · food sourcesOpen →10.04Urinary tract & sexually transmitted infectionsUTI organisms · STI table · genital ulcersOpen →10.05TORCH & neonatal infectionsCongenital infections · neonatal sepsis and meningitisOpen →10.06Bone, skin, heart & eye infectionsOsteomyelitis · cellulitis, necrotizing fasciitis · endocarditis · conjunctivitisOpen →10.07Infections in the compromised hostBy immune defect · asplenia · neutropenia · transplant · burns, CFOpen →10.08VaccinesLive vs inactivated · toxoid · conjugate · contraindicationsOpen →
11

Antimicrobials

11.01β-lactams I — penicillins & cephalosporinsMechanism · spectrum by generation · adverse effectsOpen →11.02β-lactams II, vancomycin & resistanceCarbapenems · aztreonam · vancomycin · daptomycin · resistance mechanismsOpen →11.03Protein synthesis inhibitorsAminoglycosides · tetracyclines · macrolides · clindamycin · linezolid · chloramphenicolOpen →11.04Folate antagonists, fluoroquinolones & metronidazoleTMP-SMX · fluoroquinolones · metronidazole · nitrofurantoinOpen →11.05Antimycobacterial drugsRIPE therapy · toxicities · MAC and leprosy drugsOpen →11.06Antifungal drugsAmphotericin · azoles · echinocandins · flucytosine · terbinafine, griseofulvinOpen →11.07Antiviral drugsHerpes drugs · influenza drugs · hepatitis B and C drugsOpen →11.08HIV antiretroviralsNRTI · NNRTI · protease, integrase, entry inhibitors · toxicitiesOpen →11.09Antiparasitic drugs & prophylaxisAntimalarials · antihelminthics · prophylaxis tableOpen →