STEPTRACKERHIGH-YIELD RAPID REVIEW | PATHOLOGY · BIOCHEMISTRY · MICROBIOLOGY · IMMUNOLOGY · PHARMACOLOGY

USMLE Step 1 Rapid Review

PART IImmune System BasicsChapters 01–03 · 12 pages

01

Cells & Organs

1.01Lymphoid organsBone marrow, thymus · lymph node zones · spleen · MALT · drainageOpen →1.02Innate immune cellsNeutrophils · monocytes/macrophages · dendritic cells · NK cells · mast cells, basophils, eosinophilsOpen →1.03Lymphocyte development & selectionThymic positive and negative selection · AIRE · B-cell development · VDJ recombinationOpen →1.04CD markers & surface moleculesLineage markers · costimulatory molecules · adhesion molecules · flow cytometry cluesOpen →

02

Innate Immunity

2.01Barriers, receptors & inflammationPhysical barriers · PRRs and TLRs · inflammasome · acute-phase reactants · feverOpen →2.02ComplementClassical, lectin, alternative pathways · C3b, C5a, MAC · regulators · deficienciesOpen →2.03Phagocytosis & killingRolling, adhesion, transmigration · opsonins · respiratory burst · CGD, LAD, Chédiak-HigashiOpen →

03

Adaptive Immunity

3.01MHC & antigen presentationMHC I vs MHC II · processing pathways · cross-presentation · HLA genesOpen →3.02T-cell activation & subsetsTwo-signal activation · Th1, Th2, Th17, Treg, Tfh · CD8 killing · superantigensOpen →3.03B-cell activation & class switchingT-dependent vs T-independent · germinal centers · CD40L · somatic hypermutationOpen →3.04Antibody structure & isotypesFab, Fc · heavy and light chains · IgM, IgG, IgA, IgE, IgD · functionsOpen →3.05CytokinesInterleukins by source and action · interferons · TNF · chemokines · clinical usesOpen →

PART IIImmune DysfunctionChapters 04–06 · 10 pages

04

Hypersensitivity

4.01Type I hypersensitivityIgE, mast cells · immediate and late phase · anaphylaxis · atopy · testingOpen →4.02Type II & type III hypersensitivityAntibody to cell or matrix · immune complexes · serum sickness · ArthusOpen →4.03Type IV & transfusion reactionsDelayed-type T-cell reactions · contact dermatitis · transfusion reaction typesOpen →

05

Autoimmunity

5.01Tolerance & mechanisms of autoimmunityCentral and peripheral tolerance · molecular mimicry · HLA associationsOpen →5.02AutoantibodiesAutoantibody → disease table · sensitivity vs specificityOpen →5.03Immunologic features of systemic diseaseSLE · Sjögren · scleroderma · myositis · vasculitis · sarcoidosis · IgG4Open →

06

Immunodeficiencies

6.01B-cell deficienciesXLA · CVID · selective IgA · hyper-IgM · transient hypogammaglobulinemiaOpen →6.02T-cell & combined deficienciesDiGeorge · SCID · Wiskott-Aldrich · ataxia-telangiectasia · hyper-IgE · IL-12 defectsOpen →6.03Phagocyte & complement deficienciesCGD · LAD · Chédiak-Higashi · MPO · complement and C1-INH deficiencyOpen →6.04Approach to recurrent infectionInfection pattern → defect · tests · secondary immunodeficiencyOpen →

PART IIIClinical ImmunologyChapters 07–08 · 7 pages

07

Transplant & Immunotherapy

7.01Transplant rejection & GVHDHyperacute, acute, chronic rejection · GVHD · HLA matchingOpen →7.02ImmunosuppressantsCalcineurin inhibitors · mTOR inhibitors · antimetabolites · steroids · toxicitiesOpen →7.03Therapeutic antibodies & biologics-mab targets · TNF inhibitors · checkpoint inhibitors · cytokine therapyOpen →7.04Immunologic testsELISA · flow cytometry · immunofluorescence · complement levels · skin and blood testsOpen →

08

Rapid-Fire Review

8.01Cells, markers & cytokinesOne-line identity for each cell, marker and cytokineOpen →8.02Defect → infection & diseaseImmune defect mapped to infection, test and treatmentOpen →8.03Immunology drugs & antibodiesTargets, uses and signature toxicities at a glanceOpen →